In the summer of 2007, WMU NC sponsored its very first mission trip. A group of 10 women from all over NC worked at the Gano Mission Center in Houston, TX. The center’s mission is to serve impoverished communities in the inner city of Houston by providing for the physical and spiritual needs of people. The WMU NC team worked with several of the center's ministries, which include food and clothing distribution, Kids' Clubs, Preteen/Teen Clubs, Christian Women's Job Corps, Senior Adult Ministry, English as a Second Language (ESL) classes and more. Subsequent WMU NC mission teams have served in Alaska; Houston, TX; Tijuana/Baja California, Mexico; Tahoe City, CA; Hawaii; Nada, KY; and Lebanon.

Several of those who have participated in one of the WMU NC trips are leading more trips in which women across the state will have the opportunity to participate. Tammi Ward is the volunteer coordinator for upcoming trips.